New Structured Materials in the Study of the Mechanobiological Processes Related to the Heart Failure

  • Sandra González Lana Instituto de Ciencia de Materiales de Aragón (ICMA), CSIC-Universidad de Zaragoza, Zaragoza, Spain 3. Dpto. de Física de la Materia Condensada, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain
  • Andrés Belaza Instituto de Ciencia de Materiales de Aragón (ICMA), CSIC-Universidad de Zaragoza, Zaragoza, Spain Dpto. de Física de la Materia Condensada, Facultad de Ciencias, Universidad de Zaragoza, Zaragoza, Spain
  • Alan Vigueras Group of Applied Mecahnics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Aragon, Spain, Centro Investigacion Biomedica en Red.Bioingenieria, biomateriales y nanomedicina (CIBER-BBN), Zaragoza, Aragon, Spain, Aragon Institute of Biomedical Research, Instituto de Salud Carlos III, Madrid, Madrid, Spain.
  • María Virumbrales Group of Applied Mecahnics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A), University of Zaragoza
  • Guillermo Llamazares Group of Applied Mecahnics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A), University of Zaragoza
  • Laura Asín Group of Applied Mecahnics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A), University of Zaragoza
  • Jesús M. de la Fuente Group of Applied Mecahnics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A), University of Zaragoza
  • Francisco Medel Group of Applied Mecahnics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A), University of Zaragoza Dpto. de Ingeniería Mecánica, EINA
  • Mohamed H. Doweidar Group of Applied Mecahnics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A)
  • Sara Oliván Group of Applied Mecahnics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A)
  • Luis F. Fernández Group of Applied Mecahnics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A)
  • Manuel Doblaré Group of Applied Mecahnics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A)
  • Arantxa González Centro de Investigación Médica Aplicada (CIMA), Pamplona, Spain
  • Iñaki Ochoa Group of Applied Mecahnics and Bioengineering (AMB), Aragón Institute of Engineering Research (I3A), University of Zaragoza
  • Carlos Sánchez Instituto de Ciencia de Materiales de Aragón (ICMA), CSIC-Universidad de Zaragoza Dpto. de Física de la Materia Condensada, Facultad de Ciencias

Resumen

Cardiovascular diseases are the number one of death globally. According to the World Health organization 17.7 million people died from cardiovascular diseases in 2015, representing 31% of all global deaths.  In these diseases the cardiac homeostasis is disrupted by a non-appropriate myocardium remodelling. The cardiac extracellular matrix (ECM) provides not only the biochemical environment but also a natural scaffold surrounding and connecting cardiac cells and distributing mechanical forces throughout the organ. Thus, the properties of the ECM are essential for the maintenance of the functional myocardium. Alterations in cardiac ECM structure associated with heart failure influence cell-matrix and cell-cell adhesions modifying cell shape and mechanotransduction.

The need to understand the cardiac ECM remodelling mechanisms that allow us to identify new therapeutic targets lead us to create biomimetic scaffolds which emulate the structure, topography, mechanics and chemical composition of ECM.

Here, we present the development of modulable materials for the manufacturing, by using photopolymerizable materials, of structured hydrogels with myocardium properties of stiffness and elastic modulus in physiological and pathological conditions.

Publicado
2017-06-01