Computational Analysis of the Influence of Dissolution-Diffusion and Specific Binding on Drug Transport in the Arterial Wall following Stent-based Delivery

  • Javier Escuer Gracia Applied Mechanics and Bioengineering (AMB), Instituto de Investigación en Ingeniería de Aragón (I3A), Universidad de Zaragoza
  • Estefanía Peña Baquedano Applied Mechanics and Bioengineering (AMB), Instituto de Investigación en Ingeniería de Aragón (I3A), Universidad de Zaragoza - Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)
  • Sean McGinty Division of Biomedical Engineering, University of Glasgow, UK
  • Miguel Ángel Martínez Applied Mechanics and Bioengineering (AMB), Instituto de Investigación en Ingeniería de Aragón (I3A), Universidad de Zaragoza - Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)-

Resumen

A computational model of the transport of drugs eluted from a drug-eluting stent (DES) in the arterial wall is developed to study the influence of considering a non-linear model of dissolution-diffusion in the polymeric strut coating of the stent and a non-linear saturable reversible reaction model in the tissue to describe drug specific and non-specific binding.

Publicado
2018-05-29