Collagen Density Regulates Tumour Spheroid Growth Through Cell Motility: A Computational Study

Autores/as

  • Inês Godinho Gonçalves University of Zaragoza
  • Jose Manuel García-Aznar M2BE - Multiscale in Mechanical and Biological Engineering. Instituto de Investigación en Ingeniería de Aragón (I3A)

Resumen

We aim to define the role of matrix density on tumour growth through a discrete computational framework. We integrate experimental data to characterize the dynamics of individual cellular movement, accounting for the mechanical properties of the ECM, and we evaluate how the emerging trends modulate the growth of multicellular structures.

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Publicado

2021-11-12