Dense discrete phase model for tumor cell growth analysis in fluid environments

Autores/as

  • Pau Urdeitx Diaz Applied Mechanics and Bioengineering. Universidad de Zaragoza
  • Victor Hidalgo Mechanical Engineering Department, School of Engineering and Architecture (EINA), University of Zaragoza, 50018 Zaragoza, Spain
  • Mohamed H. Doweidar Mechanical Engineering Department, School of Engineering and Architecture (EINA), University of Zaragoza, 50018 Zaragoza, Spain

DOI:

https://doi.org/10.26754/jjii3a.20227035

Resumen

Cell-cell and cell-extracellular matrix interactions play a major role in tumor growth, which involves complex molecular intercommunications. We have developed a single-cell computational model in which fluid dynamics and cell-cell interaction are coupled to evaluate the growth of cancer cells in fluidic environments. The results demonstrate that, once the cell concentration increases, the cell-cell interaction increases, decreasing cell maturation time and increasing tumor growth rate.

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Publicado

2022-07-18