@article{Cilla_Peña_Martínez_2012, title={The microcalcification influence on the ateroma plaque vulnerability}, url={https://papiro.unizar.es/ojs/index.php/jji3a/article/view/1894}, DOI={10.26754/jji-i3a.201201894}, abstractNote={Rupture of atherosclerotic plaque, which is related to maximal stress conditions in the plaque, is<br />a major cause of mortality worldwide. More careful examination of stress distributions in<br />plaques reveals that it may be caused by the local stress behaviors caused by cap thinning,<br />inflammation, macroscopic heterogeneity, and recently, the presence of microcalcifications, at<br />critical sites. However, the role of microcalcifications is not yet fully understood and most finite<br />element models of blood vessels with atheroma plaque do not consider the heterogeneity of the<br />plaque constituents at the micro-scale. The goal of the present work is to investigate the effects<br />of microcalcifications on the stress field of an atheroma plaque vessel section. This is achieved<br />by performing a parametric finite element study, assuming a plane strain hypothesis, of an<br />idealized coronary artery cross-section with eccentric atheroma plaque and one<br />microcalcification incorporated. The model was extruded at a small length in order to introduce<br />some purely 3D parameters such as the fiber orientation. Healthy (adventitia) and diseased<br />(fibrotic, lipidic and calcification) tissues were considered. The parametric analysis includes the<br />most influential geometric parameter on atheroma vulnerability and the position and dimensions<br />of the microcalcification: the fibrous cap thickness, the microcalcification ratio, angle and<br />eccentricity. In total, a large set of 108 different geometries were studied. We could conclude<br />that microcalcifications should be considered in the modeling of this kind of problems since<br />they cause a significant alteration of the vulnerable risk by increasing the maximum maximal<br />principal stress up to 40%.}, journal={Jornada de Jóvenes Investigadores del I3A}, author={Cilla, M. and Peña, E. and Martínez, M.Á.}, year={2012}, month={may}, pages={56} }