Advanced Computational Framework for Simulating Multiple Myeloma Proliferation Dynamics: Development, Calibration and Experimental Validation

Abstract

Controlling cancer cell proliferation under controlled experimental conditions remains a complex challenge due to the intricate interplay of biological, mechanical, and biochemical factors involved. This work presents 
a computational framework for multiple myeloma proliferation calibrated 
and validated against experimental in vitro data, successfully reproducing 
the characteristic proliferation dynamics observed under both free-cell and hydrogel environments.