Exploring oligonucleotide-based silencing strategies to prevent anthracycline-induced cardiotoxicity

Autores/as

DOI:

https://doi.org/10.26754/jji-i3a.202613335

Resumen

Chemotherapy-induced cardiotoxicity is a major limitation of anthracycline-based treatments such as doxorubicin. Since TOP2B has been identified as a key mediator of DOXO-induced cardiotoxicity, this work explores and optimizes shRNA- and ASO-based silencing strategies targeting TOP2B. Preliminary results support the development of chemically modified ASOs with improved therapeutic potential.

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Publicado

2026-07-17

Número

Vol. 14 (2026): Actas de la XV Jornada de Jóvenes Investigadores e Investigadoras del I3A - 9 de junio de 2026

Sección

Artículos (Ingeniería Biomédica)

Licencia

Derechos de autor 2026 Carolina Gómez, Estíbaliz Fernández Carro, Vira Sharko, Ana Rosa Remacha, Clara Alcaine, Ángel Luis García Otín, Laura Ordovás Vidal, Jesús Ciriza Astrain

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.

Cómo citar

Gómez, C., Fernández Carro, E., Sharko, V., Remacha, A. R., Alcaine, C., García Otín, Ángel L., Ordovás Vidal, L., & Ciriza Astrain, J. (2026). Exploring oligonucleotide-based silencing strategies to prevent anthracycline-induced cardiotoxicity. Jornada De Jóvenes Investigadores Del I3A, 14. https://doi.org/10.26754/jji-i3a.202613335