Computational Analysis of the Influence of Dissolution-Diffusion and Specific Binding on Drug Transport in the Arterial Wall following Stent-based Delivery

Authors

  • Javier Escuer Gracia Applied Mechanics and Bioengineering (AMB), Instituto de Investigación en Ingeniería de Aragón (I3A), Universidad de Zaragoza
  • Estefanía Peña Baquedano Applied Mechanics and Bioengineering (AMB), Instituto de Investigación en Ingeniería de Aragón (I3A), Universidad de Zaragoza - Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)
  • Sean McGinty Division of Biomedical Engineering, University of Glasgow, UK
  • Miguel Ángel Martínez Applied Mechanics and Bioengineering (AMB), Instituto de Investigación en Ingeniería de Aragón (I3A), Universidad de Zaragoza - Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN)-

DOI:

https://doi.org/10.26754/jji-i3a.201802860

Abstract

A computational model of the transport of drugs eluted from a drug-eluting stent (DES) in the arterial wall is developed to study the influence of considering a non-linear model of dissolution-diffusion in the polymeric strut coating of the stent and a non-linear saturable reversible reaction model in the tissue to describe drug specific and non-specific binding.

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Published

2018-05-29

How to Cite

Escuer Gracia, J., Peña Baquedano, E., McGinty, S., & Martínez, M. Ángel. (2018). Computational Analysis of the Influence of Dissolution-Diffusion and Specific Binding on Drug Transport in the Arterial Wall following Stent-based Delivery. Jornada De Jóvenes Investigadores Del I3A, 6. https://doi.org/10.26754/jji-i3a.201802860

Issue

Vol. 6: Actas de la VII Jornada de Jóvenes Investigadores del I3A - 8 de junio de 2018

Section

Artículos (Ingeniería Biomédica)