Collagen Density Regulates Tumour Spheroid Growth Through Cell Motility: A Computational Study

Authors

  • Inês Godinho Gonçalves M2BE - Multiscale in Mechanical and Biological Engineering. Instituto de Investigación en Ingeniería de Aragón (I3A)
  • Jose Manuel García-Aznar M2BE - Multiscale in Mechanical and Biological Engineering. Instituto de Investigación en Ingeniería de Aragón (I3A)

DOI:

https://doi.org/10.26754/jjii3a.20215963

Abstract

We aim to define the role of matrix density on tumour growth through a discrete computational framework. We integrate experimental data to characterize the dynamics of individual cellular movement, accounting for the mechanical properties of the ECM, and we evaluate how the emerging trends modulate the growth of multicellular structures.

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Published

2021-11-12

How to Cite

Godinho Gonçalves, I., & García-Aznar, J. M. (2021). Collagen Density Regulates Tumour Spheroid Growth Through Cell Motility: A Computational Study. Jornada De Jóvenes Investigadores Del I3A, 9. https://doi.org/10.26754/jjii3a.20215963

Issue

Vol. 9 (2021): Actas de la X Jornada de Jóvenes Investigadores e Investigadoras del I3A - 21 de octubre de 2021

Section

Artículos (Ingeniería Biomédica)