3D Biomimetic in Vitro Model of Self-induced Cardiac Ischemia Based on the Co-culture of Cardiomyocytes Derived from hiPSC and Primary Human Cardiac Fibroblast

Authors

  • Laura Universidad de Zaragoza
  • Sandra González-Lana
  • Nicolás Polo
  • Héctor Castro-Abril
  • Manuel M. Mazo
  • Ignacio Ochoa
  • Jesús Ciriza

DOI:

https://doi.org/10.26754/jjii3a.20239021

Abstract

Large cardiac spheroids (i.e., > 500 µm diameter) that self-induce an ischemic core were generated by co-culture of cardiomyocytes derived from induced pluripotent cells (hiPSC-CMs) and primary cardiac fibroblast (hCF). Without modification of culture conditions, spheroids’ large size allowed the recreation of a dead core, fibrotic remodelling and tissue stiffening.

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Published

2023-07-07

How to Cite

Laura, González-Lana, S., Polo, N., Castro-Abril, H., Mazo, M. M., Ochoa, I., & Ciriza, J. (2023). 3D Biomimetic in Vitro Model of Self-induced Cardiac Ischemia Based on the Co-culture of Cardiomyocytes Derived from hiPSC and Primary Human Cardiac Fibroblast . Jornada De Jóvenes Investigadores Del I3A, 11. https://doi.org/10.26754/jjii3a.20239021