Novel Fabrication Technique to Confine Hydrogels with Different Patterns inside Microfluidic Devices without Pillars

Abstract

In the field of microtechnologies applied to the simulation of controlled biological environments are the so-called organ-on-a-chip, microfluidic cell culture devices. The gradient model plays an indispensable role in this technology. Here, we present a novel microfabrication process for pillarless microfluidic platforms which enables the creation of gradients inside them.